Gastroesophageal Reflux

Il reflusso gastroesofageo

Gastroesophageal reflux affects many people. Let’s explain its symptoms and causes, starting with how the stomach works and ending with our tips for feeling better.

The problem of gastroesophageal reflux

Gastroesophageal reflux occurs when stomach juices flow back into the oesophagus and often causes unpleasant burning sensations. Gastroesophageal reflux is very common in modern society.

When this disorder persists, it is not only uncomfortable for those affected but, over time, it can cause further and more serious problems, such as ulcers, chronic oesophagitis and, sometimes, it can even develop into more serious oesophageal conditions. 

Causes of gastroesophageal reflux

There are many causes of gastroesophageal reflux, and they depend largely on an individual’s lifestyle. The most common include:

·       acute and/or chronic stress;

·       smoking

·       alcohol consumption

·       particularly spicy foods or foods rich in protein and fat

·       a build-up of free radicals

·       the presence of the bacterium Helicobacter pylori.

Looking at this list, it is easy to see why gastroesophageal reflux can be considered a “modern” disorder. Most of the factors listed are difficult to avoid in everyday life.

 

The function of gastric juices produced by the stomach

Gastric juices produced by the stomach serve to continue the digestion of food, which ideally begins during chewing. This process is necessary to make nutrients absorbable by the intestines.

To do its job, the stomach produces gastric juice, which consists of several components and has a pH of 1 — meaning it is the most acidic substance our body can produce. The main component of gastric acid responsible for its acidity ishydrochloric acid. The presence of this acid, together with pepsins, also produced by stomach cells, helps us digest most of the proteins we consume. In addition, gastric acid disinfects the food we eat. Many bacteria and viruses that may be present in food cannot survive in such an acidic environment. Gastric acid is so concentrated that it can even dissolve certain materials.

How does the stomach protect itself from gastric juices?

The stomach must protect itself from gastric juices to avoid damage, so it produces gastric mucus, whose main component is mucin. Mucin adheres to the stomach walls, creating a protective layer against gastric acidity and pepsins. In addition, the muscles around the opening between the stomach and oesophagus close tightly when we are not eating to prevent gastric acids from moving towards the oesophagus. However, due to several factors that are increasingly common in modern society, gastric juices can sometimes cross this barrier and reach the oesophagus, causing a burning sensation. This is known as gastroesophageal reflux. 

The curious case of Helicobacter pylori.

For a long time, the stomach was thought to be sterile because of its high concentration of gastric juices and acidic pH. The presence of a gram-negative bacterium was not discovered until 1983: Helicobacter pylori (H. pylori). 

Since its discovery, it has generated considerable controversy. Not only could it survive gastric acids, but several studies found that it could be a cause of gastritis and even some forms of ulcers and tumours. Our relationship with this bacterium appears to be even more complex: many people who carry Helicobacter pylori have no symptoms or particular problems. Some studies attribute this to the condition of their physiological defences. If our current health is compromised, however, H. pylori may cause imbalances. In other words, if our gastroesophageal health is compromised, the bacterium may worsen the disorders we experience through its activity.



How can gastroesophageal reflux be managed?

There are several ways to prevent the onset of gastroesophageal reflux or address the problem. In general, a healthy lifestyle and balanced diet help prevent gastroesophageal reflux. Taking care not to eat too many meals rich in protein and fatty acids helps avoid increasing stomach acidity, as does taking care not to consume too many alcoholic drinks. Finding ways to look after yourself or reduce everyday stress can also help lower stomach acidity, which affects many people exposed to stressful situations. It is important to take action when needed or, better still, prevent this condition.

 

Natural support from NATURALSALUS

NATURALSALUS offers natural support against reflux, having created DS2 REF-LUX HERBA to provide support for protecting the stomach and oesophagus from gastric juices. The herbs in this product have been selected to create an additional protective layer on the inner walls of the stomach. This extra protective layer is created especially by the presence of sodium alginate and potato starch. Sodium alginate is a polysaccharide that forms a mucilage which protects and soothes the mucous membrane. Potato starch, on the other hand, helps neutralise acidity and reduce the burning sensation caused by reflux.  Licorice and gotu kola, with their anti-inflammatory and restorative action, help limit damage caused by gastric juices. They also have a relaxing effect, helping counter nervousness and irritability.  Chamomile is known for its antispasmodic action and helps reduce stomach pain caused by muscle contractions that often accompany reflux. Chamomile is also used to help counteract the effects of  Greek mastic makes the environment less hospitable toHelicobacter pylori, a bacterium that can often cause reflux or further aggravate symptoms in people at risk. Finally, sulforaphane not only has antioxidant and protective effects but also inhibits the growth of the bacterium Helicobacter pylori.

Research sources

R H Hunt, M Camilleri, S E Crowe, E M El-Omar, J G Fox, E J Kuipers, P Malfertheiner, K E L McColl, D M Pritchard, M Rugge, A Sonnenberg, K Sugano, and J Tack, The stomach in health and disease. Gut. 2015 Oct; 64(10): 1650–1668. Published online 2015 Sep 4. doi: 10.1136/gutjnl-2014-307595.

Denisse Bravo, Anilei Hoare, Cristopher Soto, Manuel A Valenzuela, and Andrew FG Quest, Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects. World J Gastroenterol. 2018 Jul 28; 24(28): 3071–3089. Published online 2018 Jul 28. doi: Asima Bhattacharyya, Ranajoy Chattopadhyay, Sankar Mitra, and Sheila E.Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases. Physiol Rev. 2014 Apr; 94(2): 329–354.
www.humanitas.it/malattie/helicobacter-pylori-infezione

Young Hee Choi, You-Jin Kim, Hee-Sung Chae, Young-Won Chin, In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice. Planta Med. 2015 May;81(7):

Mustafa Cemek, Ezgi Yilmaz, Mehmet Emin Büyükokuroğlu, Protective effect of Matricaria chamomilla on ethanol-induced acute gastric mucosal injury in rats. Pharm Biol. 2010 Jul;48(7):757-63. doi: 10.3109/1388020

Tomofumi Miyamoto, Tadayoshi Okimoto, and Michihiko Kuwano, Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori. Nat Prod Bioprospect.

Akinori Yanaka, Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress. Review. Curr Pharm Des. 2017;23(27):4066-4075. doi: 10.2174/138161282366617020710

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